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  • Title: Repeat low-grade squamous intraepithelial cytology with unsatisfactory colposcopy treated by the loop electrosurgical excision procedure: a retrospective study.
    Author: Liu Y, Li C, Wang J, Zhang W.
    Journal: Eur J Gynaecol Oncol; 2010; 31(6):632-5. PubMed ID: 21319505.
    Abstract:
    INVESTIGATION: To evaluate the value of the loop electrosurgical excision procedure (LEEP) for repeat low-grade squamous intraepithelial lesions (LSIL) with unsatisfactory colposcopy and the outcomes of postconization. METHODS: We performed LEEP in 136 patients and followed them up with colposcopy, cytology, and high-risk HPV (HR-HPV) detection using Hybrid Capture II (HCII). RESULTS: 55.1% of women had CIN 1 in the specimen, 17.6% had CIN 2-3, and 27.2% had no lesion. The sensitivity of detecting persistent/recurrent disease can reach 90.9% when positive post-treatment HR-HPV or first abnormal cervical cytology after LEEP are found, and the specificity is 95.3% when positive post-treatment HR-HPV coexisting with first abnormal cervical cytology after LEEP are detected. CONCLUSION: Repeat LSIL with unsatisfactory colposcopy implies a significant risk of CIN 2-3. LEEP is a rational option to those patients with high-risk HPV infection or dysplastic endocervical curettage. Post-treatment follow-up of patients should include both cytology and HR-HPV testing.
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