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  • Title: Oral administration of recombinant human acid α-glucosidase reduces specific antibody formation against enzyme in mouse.
    Author: Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Hachimura S, Kobayashi H.
    Journal: Mol Genet Metab; 2011 May; 103(1):98-100. PubMed ID: 21320791.
    Abstract:
    Animal and human studies of enzyme replacement therapy for Pompe disease have indicated that antibodies generated against the infused recombinant human acid α-glucosidase (rhGAA) can negatively impact therapeutic outcome. In this study, we show that oral administration of rhGAA into mice can reduce the titer of anti-rhGAA antibody following immunization with rhGAA. Oral administration of rhGAA is safe and antigen specific, it offers advantages over other immunosuppressive drugs.
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