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  • Title: Protective effects of erdosteine on amikacin induced visual evoked potentials and lipid peroxidation alterations.
    Author: Derin N, Akpınar D, Ozcan F, Yargıçoğlu P, Aslan M.
    Journal: J Ocul Pharmacol Ther; 2011 Apr; 27(2):131-5. PubMed ID: 21323471.
    Abstract:
    PURPOSE: We aimed at investigating the effect of erdosteine administration on amikacin induced visual evoked potentials (VEPs) alterations in rats. METHODS: For this purpose, forty male Wistar rats were divided into 4 groups: control, amikacin treated, erdosteine treated, and amikacin + erdosteine treated. Amikacin (600 mg/kg/day) was applied as a single dose of intramuscular injection for 14 days, and 10 mg/kg/day erdosteine was given by gastric gavage for the same period. We recorded all VEP components and measured plasma thiobarbituric acid reactive substance (TBARS) levels in all groups. RESULTS: Amikacin increased the latencies of all VEP components (P1, N1, P2, N2, and P3) and elevated plasma TBARS levels compared with control and erdosteine treated rats (p < 0,01). However, prolonged latencies of VEP components in amikacin treated rats returned to control levels after erdostein administration. Treatment of amikacin and erdosteine together significantly decreased plasma TBARS levels (0.05 ± 0.018 nmol/g protein) compared with amikacin group (0.12 ± 0.038 nmol/g protein). CONCLUSIONS: These results show that erdosteine has a protective effect on amikacin induced changes in the visual system.
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