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  • Title: Cerebral granular cell tumor (myoblastoma) in a dog: case report and literature review.
    Author: Parker GA, Botha W, Van Dellen A, Casey HW.
    Journal: Cornell Vet; 1978 Oct; 68(4):506-20. PubMed ID: 213238.
    Abstract:
    An infiltrative granular cell tumor (myoblastoma) occurred in the superficial parieto-occipital cortex of an ataxic 12-year-old dog. The neoplasm was characterized by cells with numerous small PAS-positive, diastase-resistant cytoplasmic granules. The neoplasm also had numerous cells with large globular PAS-positive bodies (angulate bodies). Ultrastructurally, the neoplastic cells were characterized by numerous homogenous electron-dense, sharply bounded granules and large pleomorphic, indistinctly bounded granules. The angulate bodies were composed of 8- to 10-nm fibrils, a few of which formed parallel arrays or tubule-like structures. This represents the first report of a granular cell tumor in the central nervous system of the dog.
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