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  • Title: Water-soluble pradimicin derivatives, synthesis and antifungal evaluation of N,N-dimethyl pradimicins.
    Author: Oki T, Kakushima M, Nishio M, Kamei H, Hirano M, Sawada Y, Konishi M.
    Journal: J Antibiot (Tokyo); 1990 Oct; 43(10):1230-5. PubMed ID: 2132569.
    Abstract:
    Three N,N-dimethyl pradimicins were synthesized by reductive alkylation of pradimicins A, E and FA-2 and evaluated for antifungal activity, water solubility and acute toxicity in mice. They showed in vitro antifungal activity superior to pradimicin A. N,N-Dimethylpradimicins E and FA-2 showed great improvement in water solubility and animal tolerance. N,N-Dimethylpradimicin FA-2 was effective in 3 experimental in vivo fungal infection models.
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