These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Impact of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio on long-term outcome in patients undergoing percutaneous coronary intervention.
    Author: Matsumoto I, Miyake Y, Mizukawa M, Takagi Y.
    Journal: Circ J; 2011; 75(4):905-10. PubMed ID: 21325724.
    Abstract:
    BACKGROUND: Several studies have demonstrated that the low-density lipoprotein cholesterol/high-denisty lipoprotein-cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease. The aim of the present study was to determine whether the LDL-C/HDL-C ratio would affect outcome in patients after percutaneous coronary intervention (PCI). METHODS AND RESULTS: Six-hundred-eighty-seven participants who underwent successful PCI for acute coronary syndromes or stable angina were enrolled. They were divided into 3 groups on the basis of the LDL-C/HDL-C ratio recorded 6 months after PCI: those with LDL-C/HDL-C≤1.5 (n=125); 1.5<LDL-C/HDL-C≤2.0 (n=205); LDL-C/HDL-C>2 (n=357). In the 3 groups, the incidence of major adverse cardiac events (MACE) was measured during the 5 years after baseline evaluation. MACE was defined as cardiac death, non-fatal myocardial infarction, new lesions, and restenosis. The median follow-up duration was 33 months. Kaplan-Meier analysis demonstrated that patients with LDL-C/HDL-C≤1.5 had a significantly lower incidence of MACE after PCI than patients with 1.5<LDL-C/HDL-C≤2.0 (P=0.014) or with LDL-C/HDL-C>2.0 (P<0.001). In addition, Cox proportional hazards analysis indicated that the LDL-C/HDL-C ratio was correlated with the incidence of MACE (HR=1.39, 95% confidence interval: 1.20-1.61, P<0.001). CONCLUSIONS: The LDL-C/HDL-C ratio had an impact on long-term outcome in patients undergoing PCI.
    [Abstract] [Full Text] [Related] [New Search]