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  • Title: Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.
    Author: Cowley PM, Baker J, Buchanan KI, Carlyle I, Clark JK, Clarkson TR, Deehan M, Edwards D, Kiyoi Y, Martin I, Osbourn D, Walker G, Ward N, Wishart G.
    Journal: Bioorg Med Chem Lett; 2011 Apr 01; 21(7):2034-9. PubMed ID: 21334892.
    Abstract:
    The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.
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