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  • Title: Synthesis of biphenyl-2-carbonitrile derivatives via a palladium-catalyzed sp2 C-H bond activation using cyano as a directing group.
    Author: Li W, Xu Z, Sun P, Jiang X, Fang M.
    Journal: Org Lett; 2011 Mar 18; 13(6):1286-9. PubMed ID: 21338092.
    Abstract:
    Pd(II)-catalyzed aromatic C-H bond activation using cyano as a directing group was carried out in TFA medium. Biphenyl-2-carbonitrile derivatives were therefore synthesized from aryl nitriles and aryl halides in moderate to good yields.
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