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  • Title: Efficacy of adenosine deaminase in the diagnosis of pleural effusions.
    Author: Gupta DK, Suri JC, Goel A.
    Journal: Indian J Chest Dis Allied Sci; 1990; 32(4):205-8. PubMed ID: 2134231.
    Abstract:
    Adenosine deaminase (ADA) activity was studied in 53 patients with pleural effusions. Patients with tuberculous pleural effusion (36) had significantly higher ADA activity (77.68 IU/L; P less than 0.001) in comparison to malignant (14.47 IU/L) and parapneumonic (28.65 IU/L) effusions. When tested with a reference limit of over 50.75 IU/L, the specificity of ADA activity was found to be 94.1 per cent. With a sensitivity of 100 per cent, low cost and easy performance pleural fluid ADA activity is proposed as a routine investigation for etiological diagnosis in pleural effusion.
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