These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prion diseases of yeast: amyloid structure and biology.
    Author: Wickner RB, Edskes HK, Kryndushkin D, McGlinchey R, Bateman D, Kelly A.
    Journal: Semin Cell Dev Biol; 2011 Jul; 22(5):469-75. PubMed ID: 21345375.
    Abstract:
    Prion "variants" or "strains" are prions with the identical protein sequence, but different characteristics of the prion infection: e.g. different incubation periods for scrapie strains or different phenotype intensities for yeast prion variants. We have shown that infectious amyloids of the yeast prions [PSI+], [URE3] and [PIN+] each have an in-register parallel β-sheet architecture. Moreover, we have pointed out that this amyloid architecture can explain how one protein can faithfully transmit any of several conformations to new protein monomers. This explains how proteins can be genes.
    [Abstract] [Full Text] [Related] [New Search]