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  • Title: Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens.
    Author: Wang JR, Shen Q, Fang L, Peng SY, Yang YM, Li J, Liu HL, Guo YW.
    Journal: Steroids; 2011 May; 76(6):571-6. PubMed ID: 21349279.
    Abstract:
    Five new pregnane steroids, toonasterones A (1), B (2), (Z)-aglawone (3), (Z)-toonasterone C (4), and (E)-toonasterone C (5), were isolated from the stem bark of Toona ciliata var. pubescens. Their structures were elucidated by means of detailed spectroscopic (IR, MS, and 2D NMR) analysis, and the stereochemistry of 1 was secured by X-ray diffraction analysis. (Z)-aglawone (3) exhibited moderate inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), a potential drug target for treatment of type-II diabetes and obesity, with an IC(50) value of 1.12 μg/mL.
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