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  • Title: Serological response to trivalent inactive influenza vaccine in HIV-infected children with different immunologic status.
    Author: Kosalaraksa P, Srirompotong U, Newman RW, Lumbiganon P, Wood JM.
    Journal: Vaccine; 2011 Apr 05; 29(16):3055-60. PubMed ID: 21349365.
    Abstract:
    Influenza vaccination is usually recommended for HIV-infected children. One hundred and twenty seven HIV-infected and twenty-one HIV-uninfected children aged ≥6 months to <18 years, all of whom were naïve to influenza vaccine, were enrolled to receive an influenza Trivalent Inactivated Vaccine (TIV). In the HIV group, the post-vaccination immune response (geometric mean titer, seroconversion and seroprotection rates) correlated with their immunological status before vaccination. The HIV-infected children with no immunosuppression had comparable serological response to HIV-uninfected children. For moderately and severely immunosuppressed HIV groups, two doses of TIV resulted in greater serological responses and should be recommended in these groups.
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