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  • Title: [In vitro and in vivo anti-influenza virus activity of ribavirin injection].
    Author: Gao RM, Li XQ, He WY, Jiang JD, Li YH.
    Journal: Yao Xue Xue Bao; 2010 Mar; 45(3):403-7. PubMed ID: 21351521.
    Abstract:
    Ribavirin is a broad-spectrum inhibitor against several unrelated DNA or RNA viruses in vitro and in vivo. In this paper the in vitro and in vivo study of anti-influenza virus activity of ribavirin (RBV) injection had been reported. The in vitro antiviral activity of ribavirin injection against influenza virus A and B was studied by CPE. The in vivo protective action of ribavirin injection against influenza A/FM/1/47(H1N1) mouse adapted strain infected mouse was studied with mouse model. The results showed ribavirin injection has strong inhibitory activity against 7 virus strains tested in vitro. Ribavirin injection could significantly increase virus infected mouse survival rate and survival days and improve lung pathogen and lung index.
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