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  • Title: [Protective effect of shenfu injection on kidney against ischemia-reperfusion injury in rats].
    Author: Li Y, Wang Y, Li J, Zhang TM.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2011 Jan; 42(1):41-3, 77. PubMed ID: 21355298.
    Abstract:
    OBJECTIVE: To investigate the effect of Shenfu injection on ischemia-reperfusion injury of rat kidney and its mechanism. METHODS: Fifty-five male SD rats were randomly divided into 5 groups: sham operation group (Sham group), Ischemia-reperfusion group (IR group), Shenfu injection (5 mL/kg) treated group (SF5 + IR group), Shenfu Injection (10 mL/kg) treated group (SF10+IR group) and Shenfu Injection (15 mL/kg) treated group (SF15+IR group). The rats were anesthetized with valebarbitone. Bilateral kidneys were exposed through midline incision. Right kidney was removed and left renal pedicels were occluded for 50 min with a traumatic mini-clamp then unclamped for 24 h. Animals in (SF5+IR group), (SF10+IR group) and (SF15+IR group) received Shenfu Injection of 5 mL/kg, 10 mL/kg and 15 mL/kg respectively through intraperitoneal injection every day for 7 days. At 24 hours after reperfusion, blood and renal tissue were taken for examination. RESULTS: Ischemia-reperfusion injury rat model was established successfully. The level of serum BUN, CREA and MDA were lower in (SF5+IR) group and (SF10+IR)group and (SF15+IR) group than in IR group (P < 0.05). The level of SOD in (SF5+IR) group and (SF10+IR) group and (SF15+IR) group increased significantly than in IR group (P < 0.05). Furthermore, all of the changes were observed in a dose-dependent manner, (SF15 + IR) group demonstrated the best effect by compared with others (P < 0.05). CONCLUSION: Shenfu injection can protect rats against acute renal ischemia-reperfusion injury by increasing SOD activity and decreasing MDA content.
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