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  • Title: Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region.
    Author: Egawa T, Koide Y, Hanaoka K, Komatsu T, Terai T, Nagano T.
    Journal: Chem Commun (Camb); 2011 Apr 14; 47(14):4162-4. PubMed ID: 21359330.
    Abstract:
    We present a design strategy for fluorescence probes with a high off/on activation ratio in the red wavelength region, based on a novel fluorescein analogue in which the O atom at the 10 position of the xanthene chromophore is replaced with a Si atom. To demonstrate the usefulness of this strategy, we designed and synthesized a red-fluorescent probe for β-galactosidase, and showed that it works in live HEK293 cells.
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