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  • Title: [Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors].
    Author: Han B, Huan Y, Lin ZY, Li P, Shen ZF, Yin DL, Huang HH.
    Journal: Yao Xue Xue Bao; 2010 Nov; 45(11):1379-84. PubMed ID: 21361038.
    Abstract:
    To research the structure-activity relationship (SAR) of glycinamide-bearing compounds that used as inhibitors of dipeptidyl peptidase IV (DPP-IV), P32/98 and compound A were chosen as the leading compounds, heterocycles containing nitrogen atom were introduced to form amide, and different residues on a-position of carbonyl were designed. The nineteen designed compounds were synthesized by a simple route and were evaluated as inhibitors of DPP-IV. All of the structures were characterized by 1H NMR and HRMS. The preliminary SAR result was obtained.
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