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  • Title: Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia.
    Author: Bauters T, Mondelaers V, Robays H, De Wilde H, Benoit Y, De Moerloose B.
    Journal: Int J Clin Pharm; 2011 Feb; 33(1):58-60. PubMed ID: 21365395.
    Abstract:
    CASE: We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy. CONCLUSION: Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.
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