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  • Title: Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates.
    Author: Wu Y, Qi SB, Wu FF, Zhang XC, Li M, Wu J, Chan AS.
    Journal: Org Lett; 2011 Apr 01; 13(7):1754-7. PubMed ID: 21366341.
    Abstract:
    A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates.
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