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  • Title: Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity.
    Author: Hodage AS, Phadnis PP, Wadawale A, Priyadarsini KI, Jain VK.
    Journal: Org Biomol Chem; 2011 Apr 21; 9(8):2992-8. PubMed ID: 21369624.
    Abstract:
    A series of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives has been synthesized. The glutathione peroxidase like catalytic activity of these compounds has been studied in a model system, in which reduction of hydrogen peroxide with dithiothreitol (DTT(red)), in the presence of an organoselenium compound was investigated by (1)H NMR spectroscopy. All these compounds exhibit GPx like catalytic activities and the catalytic reaction proceeds through a selenoxide intermediate, identified by (77)Se{(1)H} NMR spectroscopy.
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