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  • Title: IgA-mediated autoimmune hemolytic anemia in an infant.
    Author: McGann PT, McDade J, Mortier NA, Combs MR, Ware RE.
    Journal: Pediatr Blood Cancer; 2011 May; 56(5):837-9. PubMed ID: 21370419.
    Abstract:
    Autoimmune hemolytic anemia (AIHA) is characterized by the presence of autoantibodies, most frequently of the IgG isotype, directed against erythrocyte surface antigens. The direct antiglobulin test (DAT) is the critical laboratory test for the diagnosis of AIHA, but is negative in 3-11% of cases. In these cases of DAT negative AIHA, a wider spectrum of clinical data including more specialized testing for erythrocyte autoantibodies may be required. We describe the unique and challenging case of an infant with corticosteroid-responsive, DAT negative AIHA, in which specialized gel card testing identified an isolated IgA autoantibody on the erythrocyte surface.
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