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  • Title: Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension.
    Author: Lattion AL, Flückiger JP, Waeber B, Nussberger J, Aubert JF, Brunner HR.
    Journal: Experientia; 1990 Jan 15; 46(1):69-72. PubMed ID: 2137092.
    Abstract:
    The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n = 11) or a regular-sodium diet (n = 10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.
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