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  • Title: Dynamics of Pneumocystis carinii air shedding during experimental pneumocystosis.
    Author: Choukri F, Aliouat el M, Menotti J, Totet A, Gantois N, Garin YJ, Bergeron V, Dei-Cas E, Derouin F.
    Journal: J Infect Dis; 2011 May 01; 203(9):1333-6. PubMed ID: 21372312.
    Abstract:
    To better understand the diffusion of Pneumocystis in the environment, airborne shedding of Pneumocystis carinii in the surrounding air of experimentally infected rats was quantified by means of a real-time polymerase chain reaction assay, in parallel with the kinetics of P. carinii loads in their lungs. P. carinii DNA was detected in the air 1 week after infection and increased until 4-5 weeks after infection before stabilizing. A significant correlation was shown between lung burdens and the corresponding airborne levels, suggesting the possibility of estimating the fungal lung involvement through quantification of Pneumocystis in the exhaled air.
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