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  • Title: Thrombolysis with reteplase for recurrent mechanical heartvalve thrombosis.
    Author: Akhtar N, Khan YJ, Ahmed W.
    Journal: J Pak Med Assoc; 2011 Feb; 61(2):189-92. PubMed ID: 21375177.
    Abstract:
    Thrombotic occlusion of a prosthetic valve continues to be an uncommon but life threatening complication of mechanical valves. However, recurrent prosthetic valve thrombosis is yet a rare complication. Urokinase and tissue plasminogen activator (tPA) have previously been used with success in cases of recurrent thrombus formation and/or failure of streptokinaSe treatment. We report the first three cases of recurrent prosthetic mitral valve thrombosis in Pakistan which were treated with Reteplase that resulted in re-establishment of adequate blood flow across the valve with reduction of mean gradient to normal.
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