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  • Title: The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study.
    Author: Brown VL, Jane White KA.
    Journal: Math Biosci; 2011 Jun; 231(2):126-34. PubMed ID: 21377481.
    Abstract:
    Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
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