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  • Title: Flavone-catalyzed apoptosis in Scutellaria baicalensis.
    Author: Hirunuma M, Shoyama Y, Sasaki K, Sakamoto S, Taura F, Shoyama Y, Tanaka H, Morimoto S.
    Journal: Phytochemistry; 2011 Jun; 72(8):752-60. PubMed ID: 21377703.
    Abstract:
    In response to mechanical damage, roots of Scutellaria baicalensis undergo cell death within 24h. The flavone baicalein was identified as the factor regulating apoptosis in the damaged roots of S. baicalensis. Plant apoptosis is known to be triggered by oxidative damage of DNA through oxidative bursts, whereas baicalein causes apoptosis in Scutellaria cells by a copper-dependent oxidation of nuclear DNA without inducing an oxidative burst. S. baicalensis possesses an interesting system for quickly producing this apoptosis-inducing flavone in its cells. Intact Scutellaria cells contain little baicalein but store a large amount of baicalin (baicalein 7-O-β-D-glucuronide). Stress treatment of Scutellaria cells immediately initiates hydrolysis of baicalin by endogenous β-glucuronidase, and the resulting baicalein is immediately translocated to the nucleus, leading to apoptosis. Thus, S. baicalensis possesses a unique apoptosis-inducing system that is linked with metabolism of baicalin.
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