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  • Title: Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia.
    Author: Pearce RK, Seeman P, Jellinger K, Tourtellotte WW.
    Journal: Eur Neurol; 1990; 30 Suppl 1():9-14. PubMed ID: 2138080.
    Abstract:
    Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28-34% in post-mortem Parkinson's diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consistently elevated in Parkinson's diseased striata from patients who have not been medicated with L-dopa pre-mortem. Both these receptors are down-regulated by L-dopa pre-mortem. In schizophrenia, however, while the density of D1 receptors is similar to control, the D2 receptors are consistently elevated.
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