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  • Title: Cytotoxic clerodane diterpenes from Casearia rupestris.
    Author: Vieira-Júnior GM, Dutra LA, Ferreira PM, de Moraes MO, Costa Lotufo LV, Pessoa Cdo Ó, Torres RB, Boralle N, Bolzani Vda S, Cavalheiro AJ.
    Journal: J Nat Prod; 2011 Apr 25; 74(4):776-81. PubMed ID: 21381705.
    Abstract:
    Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.
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