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  • Title: Decreased production and responsiveness of interleukin 2 in lymphocytes of patients with nephrotic syndrome.
    Author: Hinoshita F, Noma T, Tomura S, Shiigai T, Yata J.
    Journal: Nephron; 1990; 54(2):122-6. PubMed ID: 2138253.
    Abstract:
    Production of and responsiveness to interleukin 2 (IL-2) were evaluated in lymphocytes from 18 patients with nephrotic syndrome. The IL-2 production of T cells, when stimulated with autologous non-T cells separated on a polystyrene resin column, was significantly decreased in patients with minimal-change nephrotic syndrome. No significant difference in the level of IL-2 production was noted between minimal-change nephrotic syndrome patients in the nephrotic stage and those in remission. The IL-2 production was also significantly decreased in lymphocytes from patients with membranous nephropathy. The responsiveness to IL-2 was inconstant among patients with nephrotic syndrome. These results indicate that the immune system of regulating IL-2 production is impaired in patients with nephrotic syndrome.
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