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  • Title: Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.
    Author: Elia EM, Pustovrh C, Amalfi S, Devoto L, Motta AB.
    Journal: Fertil Steril; 2011 Jun 30; 95(8):2534-7.e1. PubMed ID: 21382619.
    Abstract:
    Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.
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