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  • Title: Identification of new defective interfering RNA species associated with porcine reproductive and respiratory syndrome virus infection.
    Author: Xiao CT, Liu ZH, Yu XL, Ge M, Li RC, Xiao BR, Zhou HR.
    Journal: Virus Res; 2011 Jun; 158(1-2):33-6. PubMed ID: 21385595.
    Abstract:
    In the present study, seven new defective interfering (DI) RNA species of porcine reproductive and respiratory syndrome virus (PRRSV) were identified. RT-PCR, Northern blot and sequence analyses indicated that these DI RNA specie have deletions of 8513-9176 nucleotides located between Nsp1/Nsp2 and Nsp10. Compared with the previous DI RNAs of PRRSV reported, they have three distinct characteristics: much smaller deletion sizes; different nucleotide repeats (2-12nt) used in the junction sites and in-frame deletions. The results further suggested that the similarity-assisted RNA recombination may be the main cause of generation of DI RNAs in PRRSV and probably in other arteriviruses.
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