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  • Title: Vilsmeier reaction of 3-aminopropenamides: one-pot synthesis of pyrimidin-4(3H)-ones.
    Author: Zhang R, Zhang D, Liang Y, Zhou G, Dong D.
    Journal: J Org Chem; 2011 Apr 15; 76(8):2880-3. PubMed ID: 21391701.
    Abstract:
    A facile one-pot synthesis of pyrimidin-4(3H)-ones was developed via reactions of a series of readily available 3-aminopropenamides with varied Vilsmeier reagents, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
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