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  • Title: Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives.
    Author: Wang S, Shao W, Li H, Liu C, Wang K, Zhang J.
    Journal: Eur J Med Chem; 2011 May; 46(5):1914-8. PubMed ID: 21392862.
    Abstract:
    Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5-dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
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