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  • Title: TREM-1 interaction with the LPS/TLR4 receptor complex.
    Author: Arts RJ, Joosten LA, Dinarello CA, Kullberg BJ, van der Meer JW, Netea MG.
    Journal: Eur Cytokine Netw; 2011 Mar; 22(1):11-4. PubMed ID: 21393102.
    Abstract:
    Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors. In this study, several lines of evidence are presented that TREM-1 interacts with the toll-like receptor 4 (TLR4) receptor complex, or is a component of this complex. Blocking anti-TREM-1 antibodies specifically inhibited LPS-induced TNF-α production, while the alternative approach of blocking TLR4 by a specific inhibitor led to a down-regulation of the effects of TREM-1 cross-linking. These data are in line with the TLR4-TREM1 co-localization in human neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with the TLR4/LPS-receptor complex.
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