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  • Title: Histamine and TNF-alpha release by rat peritoneal mast cells stimulated with Trichomonas vaginalis.
    Author: Im SJ, Ahn MH, Han IH, Song HO, Kim YS, Kim HM, Ryu JS.
    Journal: Parasite; 2011 Feb; 18(1):49-55. PubMed ID: 21395205.
    Abstract:
    Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis. Les mastocytes sont observés en quantité importante dans les sécrétions vaginales de patientes infectées par T. vaginalis. Cette étude explore pourquoi T. vaginalis induit la migration des mastocytes et leur production de TNF-α et d’histamine. Des mastocytes péritonéaux du rat ont été utilisés pour cette étude. Les produits d’excrétion-sécrétion de T. vaginalis induisent une augmentation de la migration chémotactique des mastocytes, et les mastocytes ainsi activés par T. vaginalis augmentent leur production d’histamine et de TNF-α. Les mastocytes seraient donc impliqués dans la réaction inflammatoire à T. vaginalis.
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