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  • Title: 1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia.
    Author: Uhl I, Mavrogiorgou P, Norra C, Forstreuter F, Scheel M, Witthaus H, Ozgürdal S, Gudlowski Y, Bohner G, Gallinat J, Klingebiel R, Heinz A, Juckel G.
    Journal: J Psychiatr Res; 2011 Sep; 45(9):1135-9. PubMed ID: 21397254.
    Abstract:
    Using proton magnetic resonance spectroscopy biochemical characteristics in early stages of schizophrenia were examined. N-acetylaspartate, choline and creatine were measured in hippocampus, anterior cingulate gyrus (ACC) and medial prefrontal cortex (mPFC) of 24 first episode and 30 ultra-high risk patients. Careful LCModel analyses revealed no differences between the patient groups and 31 healthy controls, casting doubt upon the idea of metabolic changes in early stages of psychosis.
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