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  • Title: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
    Author: Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.
    Journal: Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2468-71. PubMed ID: 21398123.
    Abstract:
    By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
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