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  • Title: Expression of v-fms and c-fms in the hemopoietic cell line FDC-P1.
    Author: Dibb NJ, Green SM, Ralph P.
    Journal: Growth Factors; 1990; 2(4):301-11. PubMed ID: 2140043.
    Abstract:
    A hemopoietic cell line FDC-P1 that requires either IL-3 or GM-CSF to survive and proliferate was infected with retroviruses that expressed either c-fms, which encodes the receptor for M-CSF, or v-fms, which is an oncogenic derivative of c-fms. The expression of c-fms allowed FDC-P1 to grow in the absence of IL-3 or GM-CSF provided that M-CSF was present. The M-CSF did not, however, induce macrophage differentiation. The expression of v-fms allowed FDC-P1 to grow in the absence of any added hemopoietic growth factors, including M-CSF, although the addition of M-CSF enhanced v-fms activity. V-fms cell lines grew to a higher cell density in suspension and were tumorigenic.
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