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  • Title: Hypergammaglobulinemia in an SIV-infected rhesus macaque with a B-cell neoplasm with plasma cell differentiation.
    Author: Kramer JA, Sanders-Beer BE, Spano YE, Rhodes L, Mansfield KG.
    Journal: J Med Primatol; 2011 Jun; 40(3):200-4. PubMed ID: 21401622.
    Abstract:
    An SIV-infected rhesus macaque presented with anemia, hypercalcemia, and hyperglobulinemia. Neoplastic round cells with plasma cell morphology infiltrated multiple organs and stained immunohistochemically positive for CD45, MUM1/IRF4, CD138, VS38C, and Kappa light chain and variably positive for CD20 and CD79a, consistent with a B-cell neoplasm with plasma cell differentiation.
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