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  • Title: [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation].
    Author: Inui S, Nakamura T, Tanabe K, Ohno H, Koike C, Okuda K, Nakata C, Fujimoto H, Ohkura H, Miyazaki Y, Takahashi H.
    Journal: Kansenshogaku Zasshi; 2011 Jan; 85(1):49-53. PubMed ID: 21404607.
    Abstract:
    Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC <2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment.
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