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Title: Abnormal Ca2(+)-ATPase activity in erythrocytes of non-insulin-dependent diabetic rats. Author: Levy J, Sowers JR, Zemel MB. Journal: Horm Metab Res; 1990 Mar; 22(3):136-40. PubMed ID: 2140560. Abstract: Non-insulin-dependent diabetic (NIDD) rats have an increased Ca2(+)-ATPase activity in their kidney basolateral membranes. We find that a similar increased activity occurs in erythrocytes of the NIDD animals. This alteration in membrane ATPase activity appears to be specific for the Ca2(+)-ATPase as (Na(+) + K+) and Mg2(+)-ATPase and Na, K and Mg concentrations in the erythrocyte were not affected by the diabetic condition in these animals. Thus, abnormalities in membrane Ca2(+)-ATPase activity in the NIDD rats are not restricted to one tissue and appear to be a generalized pathology in the NIDD animals.[Abstract] [Full Text] [Related] [New Search]