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  • Title: Antineoplastic properties of Maharishi-4 against DMBA-induced mammary tumors in rats.
    Author: Sharma HM, Dwivedi C, Satter BC, Gudehithlu KP, Abou-Issa H, Malarkey W, Tejwani GA.
    Journal: Pharmacol Biochem Behav; 1990 Apr; 35(4):767-73. PubMed ID: 2140606.
    Abstract:
    Maharishi-4 (M-4), an ayurvedic food supplement, was tested for anticarcinogenic and anticancer properties against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% M-4-supplemented diet protected DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. The control animals who developed tumors when supplemented with M-4 diet for four weeks showed tumor regression in 60% of cases. There was no significant difference in the food intake or weight gain in rats who were on M-4-supplemented diet compared to control group. Possible mechanisms of action of M-4 are discussed.
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