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  • Title: Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis.
    Author: Zaidan M, Cervera-Pierot P, de Seigneux S, Dahan K, Fabiani B, Callard P, Ronco P, Aucouturier P.
    Journal: Nephrol Dial Transplant; 2011 Jun; 26(6):2047-50. PubMed ID: 21406542.
    Abstract:
    IgG4-related systemic disease is a protean disorder that covers a wide variety of lesions. We report on a patient with tubulointerstitial nephritis, lymphadenopathies, sialadenitis and retroperitoneal fibrosis. The salivary gland and kidney interstitium were infiltrated with B lymphocytes and T lymphocytes and IgG3(+) and IgG4(+) plasma cells. The overexpression of IgG1 and IgG3, in addition to IgG4, the unusual abundance of interfollicular plasma cells and CD4(+) T cells in germinal centres of lymph nodes, and the dramatic response to rituximab point to possible roles of follicular helper T cells in enhancing a skewed B-cell terminal maturation and of CD20(+) B cells in disease progression.
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