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  • Title: Comparison of alpha beta and gamma delta expressing CD3+ acute lymphoblastic leukemias.
    Author: Macintyre EA, Salloum E, Sigaux F.
    Journal: Nouv Rev Fr Hematol (1978); 1990; 32(1):95-9. PubMed ID: 2140885.
    Abstract:
    Analysis of 267 consecutive cases of acute lymphoblastic leukemias (ALL) showed that 67 (25%) of cases were of T cell lineage and that 21/67 (31%) expressed the CD3 antigen. Of 13 CD3+ T-ALLs, 7 expressed gamma delta and 6 alpha beta. Comparison of these 2 groups showed differences in clinical and immunophenotypic parameters. The patterns of rearrangement of TCR gamma and TCR delta genes and their junctional nucleotide sequences also differed between the 2 groups. Further analysis of these patients may allow the distinction of subpopulations of ALL which merit altered management.
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