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  • Title: Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes.
    Author: Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S.
    Journal: Chem Commun (Camb); 2011 Apr 28; 47(16):4667-9. PubMed ID: 21409237.
    Abstract:
    A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
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