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  • Title: Vascular endothelial differentiation in sponge matrix allografts.
    Author: Bishop DK, Sedmak DD, Leppink DM, Orosz CG.
    Journal: Hum Immunol; 1990 Jun; 28(2):128-33. PubMed ID: 2141009.
    Abstract:
    These studies test the hypothesis that vascular endothelia in sponge allografts may develop a function and phenotype resembling the high endothelial venules (HEV) in lymph nodes, thus facilitating the lymphocytic infiltration that is characteristic of allograft rejection. Using limiting dilution analysis to quantitate helper-T-cell accumulation at graft sites, immunohistologic analysis of graft reactivity with the HEV-specific monoclonal antibody MECA 325, and ex vivo lymphocyte-endothelial adhesion assays with graft tissues, we obtained evidence to suggest that HEV-like endothelia may develop at a graft site but that the process whereby lymphocytes accumulate at a graft site is more complex than was initially expected.
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