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  • Title: Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
    Author: Neuman NA, Henske EP.
    Journal: EMBO Mol Med; 2011 Apr; 3(4):189-200. PubMed ID: 21412983.
    Abstract:
    The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM).
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