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  • Title: [Ganglioside GM3 derivatives and their immunomodulating effect].
    Author: Diatlovitskaia EV, Koroleva AB, Suskova VS, Emets VI, Sutiusheva LV, Bergel'son LD.
    Journal: Bioorg Khim; 1990 Mar; 16(3):402-6. PubMed ID: 2141471.
    Abstract:
    The derivatives of ganglioside GM3-NeuLacCer. NeuLacSph and NeuAcLacSphAc-were obtained and their immunomodulating properties studied. These substances are shown to inhibit lymphocyte blast-transformation independently of their ceramide structure. On the contrary, the stimulation by the above GM3-derivatives of Con A-induced T-suppressor activity depends significantly on the structure of their ceramide moiety.
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