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  • Title: Black aorta in a patient with alkaptonuria (ochronosis).
    Author: Concistrè G, Fiorani B, Ranocchi F, Casali G, Loforte A, Musumeci F.
    Journal: J Cardiovasc Med (Hagerstown); 2011 Jun; 12(6):444-5. PubMed ID: 21415764.
    Abstract:
    A rare cause of valvular heart disease is the deposition of foreign material in the valvular tissues, including material accumulating as a result of inborn errors of metabolism of the essential amino acids. Alkaptonuria can result in accumulation of homogentisic acid. We report the case of a patient with alkaptonuria undergoing surgery for aortic valve replacement.
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