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  • Title: [Mechanism of brain Na,K-ATPase activation by adrenaline].
    Author: Aksentsev SL, Konev SV, Lyskova TI, Okun' IM, Adzerikho RD.
    Journal: Biokhimiia; 1978 Oct; 43(10):1893-9. PubMed ID: 214168.
    Abstract:
    Norepinephrine stimulates Na, K-ATPase from rat brain homogenates at concentrations of 10(-4)--10(-5) and 10(-7)--10(-8) M. A low concentration maximum is observed after 48 hrs of incubation at -20 degrees C and is not changed by the addition of alpha-tocopherol, glycerol and MAO inhibitor ipraside. The maximum observed at the mediator concentration equal to 10(-4)--10(-5) M is eliminated after treatment with EGTA. At all concentrations of norepinephrine the enzyme stimulation is removed by the alpha-adrenoblocker phentolamine. The activated enzyme reveals lower sensitivity to Ca2+ induced inhibition. The role of Ca2+ and conformational state of the membranes in the realization of the remote effect on the adrenoreceptor-Na, K-ATPase system is discussed.
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