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  • Title: Proposal of a score combining red blood cell indices for early differentiation of beta-thalassemia minor from iron deficiency anemia.
    Author: Janel A, Roszyk L, Rapatel C, Mareynat G, Berger MG, Serre-Sapin AF.
    Journal: Hematology; 2011 Mar; 16(2):123-7. PubMed ID: 21418745.
    Abstract:
    This study evaluates the diagnostic reliability of 11 red blood cells indices, together with our new index, referred to as '11T', in differentiation of beta-thalassemia minor (BTm) from iron deficiency anemia (IDA). A total of 129 patients with microcytic anemia were involved in a retrospective study, 80 with IDA and 49 with BTm. Using an automatic program, we calculated 11 discrimination indices and a new score, 11T, based on the results of these 11 tests. To confirm the interest of 11T, we performed a prospective study with 53 patients. 11T was most effective in differentiating BTm from IDA: 11T had the highest Youden's index (83%) and the best percentage of correctly identified patients (93%) and gave optimal performance in our prospective study. We proposed a score, 11T, which is able to discriminate between IDA and BTm with high specificity and high sensitivity in order to conduct the appropriate confirmatory examination.
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